3. These in turn secret profibrotic cytokines and chemokines, amplifying the inflammatory response. Chung J, Lynch D. American Journal of Roentgenology. Vancheri C, Failla M, Crimi N et-al. Temporal heterogeneity denotes different stages of disease seen on a single specimen, including normal lung, interstitial fibrosis and fibroblastic foci 4. 2002;32: 43s-55s. Pulmonary function test results may be normal in mild disease or show restriction pattern (i.e. pulmonary fibrosis; rheumatoid lung nodules; Plain radiograph. 13. Respir. Radiology 2001; 221: 600–605. Philadelphia : Wolters Kluwer Health/Lippincott Williams & Wilkins, c2008. Diagnosis of Idiopathic Pulmonary Fibrosis. The PFF has a four-star rating from Charity Navigator and is a Better Business Bureau accredited charity. Aoki T, Nagata Y, Negoro Y et-al. 1. toxic effects of certain drugs, environmental exposures, connective tissue diseases), abnormal results of pulmonary function studies, including evidence of restriction (reduced vital capacity, often with an increased FEV. domestic and occupational environmental exposures, connective tissue disease, and drug toxicity). Eur. Advances in Cancer Research. 4. Histology shows a UIP pattern which is characterized by spatial and temporal heterogeneity. 26 (145): 170051. Ionizing irradiation causes damage to lung epithelium releasing inflammatory mediators that attract inflammatory cells. It is estimated to represent between 5-10% of cases of diffuse interstitial lung disease. Unable to process the form. Radiation-induced pulmonary fibrosis is typically seen between 6 and 12 months following completion of radiotherapy course and can continue to progress for up to 2 years 1. Differentiation of radiation fibrosis from recurrent neoplasia: a role for 31P MR spectroscopy? Gruden J. American Journal of Roentgenology. Marcelo F. Benveniste, Daniel Gomez, Brett W. Carter, Sonia L. Betancourt Cuellar, Girish S. Shroff, Ana Paula A. Benveniste, Erika G. Odisio, Edith M. Marom. 2002;165 (2): 277-304. Raghu G, Remy-Jardin M, Myers JL, Richeldi L, Ryerson CJ, Lederer DJ, Behr J, Cottin V, Danoff SK, Morell F, Flaherty KR, Wells A, Martinez FJ, Azuma A, Bice TJ, Bouros D, Brown KK, Collard HR, Duggal A, Galvin L, Inoue Y, Jenkins RG, Johkoh T, Kazerooni EA, Kitaichi M, Knight SL, Mansour G, Nicholson AG, Pipavath SNJ, Buendía-Roldán I, Selman M, Travis WD, Walsh S, Wilson KC. This Review provides an updated approach to the diagnosis of idiopathic pulmonary fibrosis (IPF), based on a systematic search of the medical literature and the expert opinion of members of the … intensity-modulated radiation therapy (IMRT), stereotactic ablative radiotherapy (SBRT or SABR), sealed source radiation therapy (brachytherapy), selective internal radiation therapy (SIRT), complications of cranial radiation therapy, complications of thoracic radiation therapy, radiation-induced bone marrow MRI signal changes, radiation-induced bone marrow signal changes - MRI, usually having a geographic non-anatomical distribution, scarlike pattern: characterized by a bandlike opacity in the tumor location associated with mild volume loss, masslike pattern: characterized by a focal consolidation/groundglass in the tumor region, with or without air bronchograms or traction bronchiectasis. bibasilar reticular abnormalities with minimal ground-glass opacities at high-resolution CT: transbronchial lung biopsy or bronchoalveolar lavage shows no features to support an alternative diagnosis, insidious onset of otherwise unexplained dyspnea on exertion, bibasilar inspiratory crackles (dry or “Velcro” type). UIP with lung fibrosis is also a common pattern of auto-immune disease and drug-related lung injury. J. Respir. A knowledge of the time course of the changes with respect to radiotherapy, total dose administered, administration of chemotherapy, and shape of the portal used can all have a significant impact on the differential, and thus should be sought if the referring clinician has not provided them 2. Crit. straight lines traditionally seen in conventional radiotherapy portals) 2,6: Although MRI may have a role helping to distinguish malignancy from fibrosis, care must be taken in interpreting results as, granulation tissue, edema, and areas of necrosis can all mimic tumor nodule, especially when fibrosis is also present 7. 2011;377 (9779): 1760-9. Lynch DA, Godwin JD, Safrin S et-al. The following disease processes can result in unilateral fibrosis, which may involve the upper lobe: radiation-induced pulmonary fibrosis: if the upper lobes have been irradiated; as a complication following lung transplantation 2,4; Mnemonic upper lobe fibrosis A TEA SHOP… Care Med. Idiopathic Pulmonary Fibrosis C. Nicholas Fetko, MD Aqeel A. Chowdhry, MD Tan-Lucien H. Mohammed, MD, FCCP Key Facts Terminology Idiopathic interstitial pneumonias of unknown cause … Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials. These profibrotic mediators stimulate fibroblasts to produce extracellular matrix proteins (e.g. As such it may be less artificial in shape and more tightly restricted to the tumor (cf. Idiopathic pulmonary fibrosis (IPF) is a clinical syndrome and considered the most common and the most lethal form of pulmonary fibrosis corresponding to the histologic and imaging pattern of usual interstitial pneumonia. Although the majority of patients are asymptomatic, referred symptoms include a persistent dry cough and shortness of breath 7. With the highly conformal radiation therapies, any further increase in size or bulkiness of the residual scarlike or masslike patterns in the treated area is concerning for recurrent disease. The major and minor criteria were eliminated and only the following diagnostic criteria remain: IPF, as the name states, is idiopathic, however, there is an association with concurrent or previous history of smoking in 60% of patients and genetic factors. 10. Idiopathic pulmonary fibrosis: a disease with similarities and links to cancer biology. If pulmonary fibrosis is a long-term complication in patients with severe COVID-19, there is an unfortunate possibility of a second wave of COVID-19 related sequelae and deaths.12 Also, early recognition and acknowledgement of pulmonary fibrosis … CT can better delineate parenchymal changes including volume loss and bronchiectasis, and often demonstrates the change restricted to the distribution of the irradiated field, rather than respecting anatomical boundaries (e.g. Unable to process the form. Radiographics. Radiology 2010 … 198 (5): e44-e68. This thickened, stiff tissue makes it more difficult for your lungs to work properly. Specific combinations of HRCT and surgical lung biopsy pattern in patients subjected to surgical lung biopsy. Glazer HS, Levitt RG, Lee JK et-al. Evaluation of lung injury after three-dimensional conformal stereotactic radiation therapy for solitary lung tumors: CT appearance. 2016;206 (3): . reduced vital capacity and total lung capacity but near normal residual volume). 1. Charles HC, Baker ME, Hathorn JW et-al. It is more common in elderly men and diagnosed by: It tends to be commoner in males, with most cases presenting in those over 60 years of age. 2005;185 (6): 1531-9. Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE, Kondoh Y, Myers J, Müller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Schünemann HJ. 2016;206 (3): . 8. 198 (5): e44-e68. Combined pulmonary fibrosis and emphysema: 3D time-resolved MR angiographic evaluation of pulmonary arterial mean transit time and time to peak enhancement. Am. Changes include 1,2,4,5: Cavitation is rarely seen in the late acute phase of the radiation-induced lung injury as a consequence of pulmonary necrosis 2, and infection is a differential to consider when they are present 1,2. Though, it might be also seen in middle-aged adults, particularly in those with familial risk for pulmonary fibrosis 15. In a subgroup of patients, the imaging findings of UIP overlap with NSIP and biopsy may be necessary to obtain the correct diagnosis. Lung function tests show a restrictive pattern with a decreased diffusing capacity of the lungs for carbon monoxide (DLCO). Once the inflammation has receded, usually between 9 to 15 months after the completion date, FDG-PET is useful in differentiating radiation fibrosis from recurrent or radiation-induced malignancy, as the former will not be metabolically active 1. Patients typically present with progressive dyspnea on exertion and chronic dry cough, usually over a period of 24 months before diagnosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. ADVERTISEMENT: Supporters see fewer/no ads, Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. It is more correct to describe the characteristic imaging pattern as UIP rather than IPF, the latter term assigned for the idiopathic clinical syndrome of UIP. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Physical examination usually reveals fine end-inspiratory crackles and in severe cases finger clubbing. J. 2005;172 (4): 488-93. pleural fissures) 2. Consider pulmonary fibrosis due to a known cause, such as: ADVERTISEMENT: Supporters see fewer/no ads, Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. It is therefore also termed interstitial fibrosis. Although changes in the lung are usually confined to the irradiated field, changes in the remainder of the lung may also occasionally be seen 1. (2019) RadioGraphics. The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary fibrosis … Progressive massive fibrosis (PMF) refers to the formation of large mass-like conglomerates, predominantly in the upper pulmonary lobes, associated with radiating strands. More recently it has been shown that fibroblasts in this process demonstrate neoplastic or neoproliferative characteristics 11. 1990;154 (1): 67-8. complications related to radiation therapy, complications of abdominopelvic radiation therapy, Late phase of radiation-induced lung disease. Link, Google Scholar; 18 Raghu G, Mageto YN, Lockhart D, Schmidt RA, Wood DE, Godwin JD. 1984;143 (4): 729-30. Pathology. {"url":"/signup-modal-props.json?lang=us\u0026email="}, {"containerId":"expandableQuestionsContainer","displayRelatedArticles":true,"displayNextQuestion":true,"displaySkipQuestion":true,"articleId":16929,"mcqUrl":"https://radiopaedia.org/articles/idiopathic-pulmonary-fibrosis/questions/1579?lang=us"}. (2018) American journal of respiratory and critical care medicine. AJR Am J Roentgenol. The course of pulmonary sarcoidosis has been widely studied using clinical, chest radiographic, and pulmonary function follow-up [2,3,4,5]. Lancet. The rs35705950 single-nucleotide polymorphism (SNP)—a promoter site of an airway mucin gene (MUC5B)—is strongly associated with IPF and familial pulmonary fibrosis and not seen in other secondary causes of lung fibrosis. Thoracic radiologic abnormalities are seen at some stage in approximately 90% of patients with sarcoidosis, and an estimated 20% develop chronic lung disease leading to pulmonary fibrosis. It is of interest to the roentgenologist because of the similar appearance in the roentgenogram of fibrotic lesions that are the end-result of many different processes. Pulmonary fibrosis is a lung disease that occurs when lung tissue becomes damaged and scarred. Eur. The potential causes of pulmonary fibrosis is long, with UIP being the commonest. Please refer to the article on radiation-induced lung disease for a general discussion and radiation pneumonitis for specific discussion of acute changes. This case of severe pulmonary fibrosis demonstrates extensive honeycombing of the lungs, in a classical fasion. It should be noted that with highly conformal radiation therapy (eg. Among the many conditions associated with pulmonary fibrosis are: 1. significant acute insult to the lungs 1.1. adult respiratory distress syndrome 4 1.2. from a significant pulmonary infection 1.3. diffuse alveolar damagefrom any source 2. in… The presence of pulmonary fibrosis (in stage IV sarcoidosis) on a chest radiograph is generally associated with poor pulmonary … Idiopathic pulmonary fibrosis (IPF), accounts for more than 60% of the cases of UIP. IPF affects mainly the elderly … (2018) American Journal of Respiratory and Critical Care Medicine. 7. 4. 2010;35 (3): 496-504. (2013) ISBN:0124072038. 2. Other associated features might include chest pain, fatigue, malaise, and weight loss. Diagnosis of Idiopathic Pulmonary Fibrosis. High-resolution computed tomography in idiopathic pulmonary fibrosis: diagnosis and prognosis. Pulmonary fibrosis causes reticular (net-like) shadowing of the lung peripheries which is typically more prominent towards the lung bases It may cause the contours of the heart to be less … In 2000, the American Thoracic Society (ATS) and European Respiratory Society (ERS) jointly agreed major and minor criteria for the diagnosis of IPF in the absence of a surgical lung biopsy 5: In 2018, these criteria were revised in a collaborative statement by the ATS, ERS, Japanese Respiratory Society (JRS) and Latin American Thoracic Association (ALAT) 12. Ganesh Raghu, Martine Remy-Jardin, Jeffrey L. Myers, Luca Richeldi, Christopher J. Ryerson, David J. Lederer, Juergen Behr, Vincent Cottin, Sonye K. Danoff, Ferran Morell, Kevin R. Flaherty, Athol Wells, Fernando J. Martinez, Arata Azuma, Thomas J. Bice, Demosthenes Bouros, Kevin K. Brown, Harold R. Collard, Abhijit Duggal, Liam Galvin, Yoshikazu Inoue, R. Gisli Jenkins, Takeshi Johkoh, Ella A. Kazerooni, Masanori Kitaichi, Shandra L. Knight, George Mansour, Andrew G. Nicholson, Sudhakar N. J. Pipavath, Ivette Buendía-Roldán, Moisés Selman, William D. Travis, Simon L. F. Walsh, Kevin C. Wilson. Crit. Care Med. CT-histologic correlation of the ATS/ERS 2002 classification of idiopathic interstitial pneumonias. 2. Positive rs35705950 SNP in IPF patients is associated with slightly better prognosis and outcome. J. Respir. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. Statements-HRCT | Pulmonary Fibrosis Foundation Radiology Working Group Recommendations A radiology working group with members from the Care Center Network have collaborated to create a … For a discussion of the epidemiology of radiation-induced lung disease, please refer to the parent article: radiation-induced lung disease. 3D-CRT, IMRT, SBRT, and proton therapy), the shape of the irradiated field will not have straight edges or conform to the traditional conventional radiotherapy portals. J. Evaluating disease severity in idiopathic pulmonary fibrosis. Souza CA, Müller NL, Flint J et-al. The presence of a UIP pattern on HRCT in patients not subjected to surgical lung biopsy (. The clinical course is that of gradual deterioration and the condition carries a rather poor prognosis with median survival ranging from 2.5 to 3.5 years from the time of diagnosis (at the time of initial writing) 2. Mueller-mang C, Grosse C, Schmid K et-al. A multidisciplinary approach in a tertiary setting is strongly advised. 5. Cryptogenic fibrosing alveolitis/idiopathic pulmonary fibrosis. 15. Although the majority of patients are asymptomatic, referred symptoms include a persistent dry cough and shortness of breath 2. American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. Pulmonary fibrosis is a condition in which the lungs become scarred over time. Noble PW, Albera C, Bradford WZ et-al. When fibrosis has become established, no treatment is available, other than a follow-up to assess for tumor recurrence. AJR Am J Roentgenol. (2017) European Respiratory Review. 11. Up to 5–20% of patients with IPF have a family history of interstitial lung disease (ILD) or pulmonary fibrosis. The document defines IPF as a “chronic, progressive fibrosing interstitial pneumonia of unknown … Tice, (1) who classified all forms of pulmonary fibrosis resulting from the inhalation of dust, whether such dust be organic or inorganic, as coming under the head “Pneumonoconiosis,” writes: … Rarely, particularly nowadays with the new techniques of radiation therapy, the radiation-induced chronic lung injury has been described to evolve to chronic respiratory failure, pulmonary hypertension, or chronic c… One of the hallmarks is the absence of inflammation. 6. du Bois RM, Wells AU. Rarely, particularly nowadays with the new techniques of radiation therapy, the radiation-induced chronic lung injury has been described to evolve to chronic respiratory failure, pulmonary hypertension, or chronic cor pulmonale 2. Choi YW, Munden RF, Erasmus JJ et-al. Radiographics. 198 (5): e44-e68. Purpose: To analyze clinical and thin-section computed tomographic (CT) data from the patients with coronavirus disease (COVID-19) to predict the development of pulmonary fibrosis after hospital … edited by Jannette Collins, Eric J. Stern. {"url":"/signup-modal-props.json?lang=us\u0026email="}. Check for errors and try again. 16. Idiopathic pulmonary fibrosis: spectrum of high-resolution CT findings. Findings from both CT and PFT are similar to disorders characterized by pulmonary fibrosis, where thickened alveolar membranes and interstitial remodelling usually affect gas diffusion … 6. Wittram C, Mark EJ, Mcloud TC. Exclusion of other known causes of interstitial lung disease (e.g. 2010;35 (4): 821-9. Diagnosis of Idiopathic Pulmonary Fibrosis. 9. A long list of … Differentiation of radiation fibrosis from recurrent pulmonary neoplasm by magnetic resonance imaging. In some instances, a straight edge conforming to the irradiation portal may be evident. Academic Press. Radiation-induced pulmonary fibrosis is typically seen between 6 and 12 months following completion of radiotherapy course and can continue to progress for up to 2 years 1. If a clear demarcation conforming to the irradiation port is seen, then there is often little difficulty in making the diagnosis, especially when a history of chest radiotherapy is known. Traction bronchiectasis can also be observed, however, this is a general feature of fibrosis not specific to the UIP-pattern 4. 23 (5): 1057-71. Radiographics. The HRCT appearance of pulmonary sarcoidosis varies greatly and is known to mimic many other diffuse infiltrative lung diseases. Radiation-induced pulmonary fibrosis is the late manifestation of radiation-induced lung disease and is relatively common following radiotherapy for chest wall or intrathoracic malignancies. As pulmonary fibrosis worsens, you become progressively more short of breath.The scarring associated with pulmonary fibrosis can be caused by a multitude of factors. What every radiologist should know about idiopathic interstitial pneumonias. 24 (4): 985-97. Complications may include pulmonary hypertension, respiratory failure, pneumothorax, and lung cancer. Chest radiograph may show: pleural effusion; lower zone predominant reticular or reticulonodular pattern; volume loss in advanced … Volume loss, architectural distortion, mediastinal shift, hemidiaphragm elevation, and bronchiectasis may all be seen 2,4. Some reports have suggested a slowing of progression with treatment by pirfenidone or nintedanib 7,8. asbestos) or collagen vascular disease (e.g. 2004;230 (1): 101-8. Idiopathic pulmonary fibrosis (IPF) is a form of idiopathic interstitial pneumonia, associated a median survival of 2-5 years from the time of diagnosis. This article does not deal with the changes seen in the acute phase. Respir. Fibrosis in the lung is a process that occurs in the interstitium. 14. collagen) resulting in the excess deposition of these materials 3. Taniguchi H, Ebina M, Kondoh Y et-al. 183 (6): 788-824. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. Chest radiology. (2011) American journal of respiratory and critical care medicine. Although chest radiography is often the first diagnostic imaging study in patients with pulmonary … Radiology. scleroderma, rheumatoid arthritis), exclusion of other known causes of interstitial lung disease (e.g. differential diagnoses of airspace opacification, presence of non-lepidic patterns such as acinar, papillary, solid, or micropapillary, myofibroblastic stroma associated with invasive tumor cells. Abstract Pulmonary fibrosis is not a primary disease, but the result of a previous pulmonary infection or irritation. Review of previous imaging will usually show the progression from radiation pneumonitis (hazy opacities) progressively becoming more reticular or linear with gradual loss of volume 4. 12. Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic fibrosing interstitial pneumonia of unknown cause, limited to the lungs and associated with a histologic pattern of usual … Hasti Robbie, Cécile Daccord, Felix Chua, Anand Devaraj. Spatial heterogeneity denotes biopsy sample showing patchy lung involvement with normal lung interspace between diseased lung. Though, it might be also seen in middle-aged adults, particularly in those with familial risk for pulmonary fibrosis 15. recurrent or radiation-induced malignancy: in-field recurrence usually happen within 3 years after the completion date, increase in the size of the treated area scarlike or masslike pattern of fibrosis, bear in mind that the post-radiation fibrotic changes usually happen around 9 months but can be seen in up to 2 years after treatment completion, malignancy often lacks air bronchograms and has convex outer border, involvement of chest wall, bone, or lymph node increase may be present, FDG-PET/CT is useful as it will demonstrate increased metabolic activity in malignancies, false-positive FDG uptake in some inflammation areas may occur. But in most cases, doctors can't pinpoint what's causing the problem. AJR Am J Roentgenol. The Society of Thoracic Radiology and the Pulmonary Pathology Society also endorsed these guidelines. Symptoms include shortness of breath, a dry cough, feeling tired, weight loss, and nail clubbing. Check for errors and try again. 5. Contributions from pulmonologists, chest radiologists, and chest pathologists are crucial in reaching the correct diagnosis of IPF. (2018) American Journal of Respiratory and Critical Care Medicine. Recognizing Radiation Therapy–related Complications in the Chest. 39 (2): 344-366. Bear in mind that FDG avidity is usually present until late phases of radiation pneumonitis (3 to 9 months after treatment completion) due to the presence of residual inflammation, therefore, PET-CT is of equivocal clinical value in this period 2. diffusing capacity of the lungs for carbon monoxide (DLCO), collaborative statement by the ATS, ERS, Japanese Respiratory Society (JRS) and Latin American Thoracic Association (ALAT), diagnostic categories of UIP pattern based on HRCT chest - Fleischner Society guideline 2018, acute unilateral airspace opacification (differential), acute bilateral airspace opacification (differential), acute airspace opacification with lymphadenopathy (differential), chronic unilateral airspace opacification (differential), chronic bilateral airspace opacification (differential), osteophyte induced adjacent pulmonary atelectasis and fibrosis, pediatric chest x-ray in the exam setting, normal chest x-ray appearance of the diaphragm, posterior tracheal stripe/tracheo-esophageal stripe, obliteration of the retrosternal airspace, leflunomide-induced acute interstitial pneumonia, fibrotic non-specific interstitial pneumonia, cellular non-specific interstitial pneumonia, respiratory bronchiolitis–associated interstitial lung disease, diagnostic HRCT criteria for UIP pattern - ATS/ERS/JRS/ALAT (2011), diagnostic HRCT criteria for UIP pattern - Fleischner society guideline (2018)​, domestically acquired particulate lung disease, lepidic predominant adenocarcinoma (formerly non-mucinous BAC), micropapillary predominant adenocarcinoma, invasive mucinous adenocarcinoma (formerly mucinous BAC), lung cancer associated with cystic airspaces, primary sarcomatoid carcinoma of the lung, large cell neuroendocrine cell carcinoma of the lung, squamous cell carcinoma in situ (CIS) of lung, minimally invasive adenocarcinoma of the lung, diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH), calcifying fibrous pseudotumor of the lung, IASLC (International Association for the Study of Lung Cancer) 8th edition (current), IASLC (International Association for the Study of Lung Cancer) 7th edition (superseeded), 1996 AJCC-UICC Regional Lymph Node Classification for Lung Cancer Staging, absence of alternative causes such as drug toxicity, environmental exposure (e.g. A UIP-pattern of fibrosis is characterized by honeycombing cysts and reticular septal thickening with subpleural and posterior basal predominance. Eur Respir J Suppl. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. It tends to be commoner in males, with most cases presenting in those over 60 years of age. Effects of radiation therapy on the lung: radiologic appearances and differential diagnosis. The Pulmonary Fibrosis Foundation rates among top charities in the U.S. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. Approximately 60 to 70% of patients with sarcoidosis have characteristic … The Foundation has met … It typically occurs in male smokers 3. The CT imaging findings complement the histology. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. Am. Pirfenidone in idiopathic pulmonary fibrosis. 3. Ganesh Raghu, Martine Remy-Jardin, Jeffrey L. Myers, Luca Richeldi, Christopher J. Ryerson, David J. Lederer, Juergen Behr, Vincent Cottin, Sonye K. Danoff, Ferran Morell, Kevin R. Flaherty, Athol Wells, Fernando J. Martinez, Arata Azuma, Thomas J. Bice, Demosthenes Bouros, Kevin K. Brown, Harold R. Collard, Abhijit Duggal, Liam Galvin, Yoshikazu Inoue, R. Gisli Jenkins, Takeshi Johkoh, Ella A. Kazerooni, Masanori Kitaichi, Shandra L. Knight, George Mansour, Andrew G. Nicholson, Sudhakar N. J. Pipavath, Ivette Buendía-Roldán, Moisés Selman, William D. Travis, Simon L. F. Walsh, Kevin C. Wilson. 7. 27 (3): 595-615. These …
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